Friday, April 29, 2011
Wednesday, April 27, 2011
Tuesday, April 26, 2011
Vitamin D is activated in the lungs to fight infection
The November 15, 2008 issue of the Journal of Immunology reports that vitamin D, believed to be activated primarily by the kidneys, is also converted to its active form in lung tissue. This activation is essential for the utilization of the vitamin in the body.
"The more scientists have been studying vitamin D, the more we learn about new roles it plays in the human body," stated lead author Sif Hansdottir, MD, of the University of Iowa Carver College of Medicine.. "The active form of vitamin D is known to affect the expression of more than 200 genes, so we were interested both in the possible lung-specific production of active vitamin D and in vitamin D-dependent production of proteins that fight infections."
By studying human lung tissue samples, Dr Hansdottir and his colleagues found that an enzyme called 1 alpha-hydroxylase helps convert vitamin D stored in the lungs' airway cells into the active form of the vitamin. "When we put the storage form of vitamin D on the lung airway cells, we saw them convert it to the active form," Dr Hansdottir explained. "The next step was to investigate whether this active form could affect the expression of genes."
The team found that activated vitamin D increased the expression of a gene that controls the production of cathelicidin, which destroys bacteria, as well as the gene CD14 which produces a protein that assists cells in their recognition of potentially threatening pathogens.
"Vitamin D not only increases proteins involved in bacterial killing but also can dampen inflammation," Dr Hansdottir added. "Controlling inflammation through vitamin D is good because too much inflammation can cause problems such as sepsis and seems to contribute to autoimmune disease."
—D Dye
Astragalus compound slows telomere shortening in T lymphocytes
November 17, 2008
Telomeres are protective regions at the end of the cells' chromosomes, which shorten each time a cell divides. When telomeres become sufficiently short, cells reach a stage known as replicative senescence in which they can no longer divide.
The enzyme known as telomerase prevents telomeres from shortening when activated. Unlike most of the body's cells, immune system cells upregulate telomerase with their activation. However, with aging or chronic infection with HIV, there is an increase in the proportion of dysfunctional CD8 T-cells with short telomeres, demonstrating that telomerase has a limited effect.
"The problem is that when we're dealing with a virus that can't be totally eliminated from the body, such as HIV, the T-cells fighting that virus can't keep their telomerase turned on forever," explained UCLA AIDS Institute member Rita Effros. "They turn off, and telomeres get shorter and they enter this stage of replicative senescence."
In a study described in the November 15, 2008 issue of the Journal of Immunology, Dr Effros and her colleagues tested a compound known as TAT2, originally derived from the Chinese herb astragalus, on CD8 T-cells from HIV-infected individuals. They found that TAT2 retarded the shortening of the cells' telomeres as well as improved their production of chemokines and cytokines that help inhibit HIV replication.
"The ability to enhance telomerase activity and antiviral functions of CD8 T-lymphocytes suggests that this strategy could be useful in treating HIV disease, as well as immunodeficiency and increased susceptibility to other viral infections associated with chronic diseases or aging," the authors write.
Dr Effros added, "This has the potential to be either added to or possibly even replace the HAART (highly active antiretroviral therapy), which is not tolerated well by some patients and is also costly."
—D Dye
Sports supplement improves fitness in older individuals
Sports supplement improves fitness in older individuals
An article published online on November 7 2008 in BioMed Central's Journal of the International Society of Sports Nutrition provides evidence that beta-alanine, a dietary supplement used by athletes, improves fitness in older men and women. Beta-alanine is an amino acid that forms, in part, the dipeptide carnosine, found in muscle tissue. Ingestion of beta-alanine increases muscle carnosine, which helps maintain intracellular pH. This maintenance is necessary for normal muscle function during intense exercise. Although recent research has shown that supplementation with beta-alanine is correlated with improved exercise performance in young men and women, its effect in older individuals had not been determined.
In a double-blind trial, Jeffrey R. Stout, PhD, of the University of Oklahoma's Department of Health and Exercise Science, and his colleagues randomized 9 men and 17 women with an average age of 72.8 to receive 800 milligrams beta-alanine three times per day or a placebo for 90 days. Fitness was evaluated by electromyographic testing during cycling intervals engaged in by the participants before and after the treatment period.
At the study's conclusion, 67 percent of those who received beta-alanine demonstrated improved fitness levels, compared with 21.5 of the placebo group. "Our data suggest that 90 days of beta-alanine supplementation increases physical working capacity in elderly men and women," the authors remark in their discussion of the results. "These findings are clinically significant, as a decrease in functional capacity to perform daily living tasks has been associated with an increase in mortality, primarily due to increased risk of falls."
"This could have importance in the prevention of falls, and the maintenance of health and independent living in elderly men and women," Dr Stout concluded.
—D Dye
Monday, April 25, 2011
Saturday, April 16, 2011
"They are on the wrong side of history..."
"Legal chicanery and pitch darkness were the banker's stoutest allies."
Thursday, April 14, 2011
Saturday, April 9, 2011
Wednesday, April 6, 2011
Adam Ginsberg Scammer extraordinaire - Speedlings 2.0 !!
The second page of this blog posting explains the real deal. Worth a read even though it made me physically sick.
Click here